Pneumotox » Drug » Ibuprofen

Ibuprofen

3

l-lysine ibuprofen

Last update : 07/10/2023

I.c Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

1

II.a Pulmonary edema, noncardiogenic (NCPE)

1

II.b ARDS - Acute lung injury

1

IV.a Bronchospasm - Wheezing - Asthma

1

IV.f Severe or catastrophic bronchospasm or asthma attack (can be fatal)

1

IV.v Deterioration/exacerbation of preexisting asthma or COPD

1

V.a Pleural effusion (uni- or bilateral) (May commpany ILDs)

1

VI.b Pulmonary arterial hypertension

1

VI.y Pulmonary hypertension of the newborn (Persistent PHT)

1

VIII.a Angioedema (may cause UAO, asphyxia and death)

1

X.a DRES syndrome - DRESS-like reaction

1

X.f Anaphylaxis-Anaphylactoid reaction (can be fatal)

1

X.g Hypersensitivity reaction (may manifest with fever and/or skin, throat or airway involvement)

2

Diagnosing DIRD

1

Drug and radiation history

2

Drug singularity - Correct identification of the drug

3

Consistent timing of exposure v. onset of symptoms

4

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

5

Careful exlusion of another cause

6

Remission of symptoms with removal of drug

7

Recurrence with rechallenge (rarely advisable)

8

Causality assessment

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