Pneumotox » Drug » Dipyridamole

Dipyridamole

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Most cardiorespiratory adverse effects of the drug decribed in the context of perfusion scintigraphy

Last update : 05/12/2013

II.a Pulmonary edema, noncardiogenic (NCPE)

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IV.a Bronchospasm - Wheezing - Asthma

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IV.b Bronchospasm and angioedema

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IV.f Severe or catastrophic bronchospasm or asthma attack (can be fatal)

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IX.d Respiratory failure from ventilatory depression (due to neuromuscular blockade/paralysis)

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IX.i Respiratory arrest - Apnea

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X.f Anaphylaxis-Anaphylactoid reaction (can be fatal)

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XII.e Takotsubo (stress) cardiomyopathy

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XII.m Cardiac- cardiorespiratory/pulmonary arrest

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XII.n Cardiovascular collapse - Cardiogenic shock - Hypotension

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Diagnosing DIRD

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Drug and radiation history

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Drug singularity - Correct identification of the drug

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Consistent timing of exposure v. onset of symptoms

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Clinical, imaging, BAL, pathological pattern consistent with the specific drug

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Careful exlusion of another cause

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Remission of symptoms with removal of drug

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Recurrence with rechallenge (rarely advisable)

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Causality assessment

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