Pneumotox » Drug » Clomipramine

Clomipramine

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Last update : 20/01/2012

I.c Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

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I.d Organizing pneumonia pattern (an area or areas of consolidation on imaging)

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IX.d Respiratory failure from ventilatory depression (due to neuromuscular blockade/paralysis)

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X.a DRES syndrome - DRESS-like reaction

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XII.d Myocarditis (can be fulminant)

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XII.ay Coronary (artery) vasculitis

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XV.cb Path: Lymphocytic myocarditis

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XV.cc Path: Eosinophilic myocarditis

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XV.cm Path: Coronary vasculitis w/wo eosinophilia

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Diagnosing DIRD

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Drug and radiation history

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Drug singularity - Correct identification of the drug

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Consistent timing of exposure v. onset of symptoms

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Clinical, imaging, BAL, pathological pattern consistent with the specific drug

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Careful exlusion of another cause

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Remission of symptoms with removal of drug

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Recurrence with rechallenge (rarely advisable)

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Causality assessment

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