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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Leukotriene receptor antagonists (LTRA)
3
Last update :
03/06/2013
I - Interstitial/parenchymal lung disease
I.c
Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)
2
X - Systemic/Distant conditions, syndromes and reactions
X.e
Autoimmunity-Autoimmune conditions (+ANA, +anti-ds-DNA, +ANCAs, other auto-Abs)
1
X.h
Eosinophilic granulomatosis with polyangiitis (Churg-Strauss)
3
X.s
Vasculitis, pulmonary (w/wo AH), extrapulmonary, systemic: ANCA-positive
1
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Montelukast
Pranlukast
Zafirlukast
