Pneumotox » Drug » Chlorpromazine

Chlorpromazine

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Last update : 04/08/2012

I.c Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

1

V.d Pleural/pericardial effusion, ANA positive (DI lupus)

1

VI.a Pulmonary embolism - Venous thrombosis/thromboembolism

1

VIII.e Laryngospasm (a.k.a. laryngismus)

-

IX.b Respiratory dyskinesia

1

IX.d Respiratory failure from ventilatory depression (due to neuromuscular blockade/paralysis)

1

X.b Antiphospholipid antibodies w/wo the APL syndrome

1

X.d Lupus - Lupus syndrome (see also Vd)

1

X.f Anaphylaxis-Anaphylactoid reaction (can be fatal)

1

Diagnosing DIRD

1

Drug and radiation history

2

Drug singularity - Correct identification of the drug

3

Consistent timing of exposure v. onset of symptoms

4

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

5

Careful exlusion of another cause

6

Remission of symptoms with removal of drug

7

Recurrence with rechallenge (rarely advisable)

8

Causality assessment

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