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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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  • Drugs
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Corticosteroids, systemic (oral, parenteral)

5

X.f Anaphylaxis-Anaphylactoid reaction (can be fatal)

2
Last update : 18/06/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Adrenocorticotropic hormone (ACTH)
2
Budesonide (p.o.)
1
Corticosteroids, inhaled (ICS)
5
Methylprednisolone
2
Prednisone
5
Salt (NaCl)
1

Publications

Immediate and delayed hypersensitivity to systemic corticosteroids: 2 case reports.
Dermatitis : contact, atopic, occupational, drug 2012;23;288-90 2012
Anaphylaxis induced by glucocorticoids.
The Journal of the American Board of Family Practice 2005;18;143-6 2005
Clinical evaluation of anaphylactic reactions to intravenous corticosteroids in adult asthmatics.
Respiration; international review of thoracic diseases 2002;69;309-13 2002
Systemic allergic reactions to corticosteroids.
The Journal of asthma : official journal of the Association for the Care of Asthma 1991;28;329-39 1991
[Severe anaphylactoid reactions after intravenous corticosteroids. Report of a case and review of the literature].
Therapie 1990;45;505-8 1990

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