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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Corticosteroids, systemic (oral, parenteral)

5

XVII.e Pneumocystis jiroveci pneumonia

4
Last update : 06/04/2013
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Adrenocorticotropic hormone (ACTH)
2
Budesonide (p.o.)
1
Corticosteroids, inhaled (ICS)
5
Methylprednisolone
2
Prednisone
5
Salt (NaCl)
1

Publications

Fatal Pneumocystis jirovecii pneumonia in a HIV-negative adult.
BMJ case reports 2015 Aug 26;2015; 2015 Aug 26
Co-infection with invasive pulmonary aspergillosis and Pneumocystis jirovecii pneumonia after corticosteroid therapy.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 2013 Apr;19;342-7 2013 Apr
Prognosis of pneumocystis pneumonia complicated in patients with rheumatoid arthritis (RA) and non-RA rheumatic diseases.
Modern rheumatology 2012 Aug;22;509-14 2012 Aug
[Pneumocystis jirovecii pneumonia in non-HIV infected patients: a study of 41 cases].
Revue de pneumologie clinique 2011 Sep;67;191-8 2011 Sep
Update on the diagnosis and treatment of Pneumocystis pneumonia.
Therapeutic advances in respiratory disease 2011 Feb;5;41-59 2011 Feb
Severe pulmonary adverse effects in lymphoma patients treated with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) regimen plus rituximab.
The Korean journal of internal medicine 2010 Mar;25;86-92 2010 Mar
Acute respiratory failure due to pneumocystis pneumonia in patients without human immunodeficiency virus infection: outcome and associated features.
Chest 2005 Aug;128;573-9 2005 Aug
Pneumocystis carinii pneumonia in patients with malignant haematological diseases: 10 years' experience of infection in GIMEMA centres.
British journal of haematology 2002 May;117;379-86 2002 May
Pneumocystis carinii pneumonia in patients without acquired immunodeficiency syndrome: associated illness and prior corticosteroid therapy.
Mayo Clinic proceedings 1996 Jan;71;5-13 1996 Jan

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