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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Corticosteroids, systemic (oral, parenteral)

5

XVII.b Opportunistic pulmonary/systemic infections

5
Last update : 31/12/2013
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Adrenocorticotropic hormone (ACTH)
2
Budesonide (p.o.)
1
Corticosteroids, inhaled (ICS)
5
Methylprednisolone
2
Prednisone
5
Salt (NaCl)
1

Publications

Adverse events profile of oral corticosteroids among asthma patients in the UK: cohort study with a nested case-control analysis.
Respiratory research 2018 Apr 27;19;75 2018 Apr 27
Serious adverse effects associated with glucocorticoid therapy in patients with giant cell arteritis (GCA): A nested case-control analysis.
Seminars in arthritis and rheumatism 2017 Jun;46;819-827 2017 Jun
LONG-COURSE ORAL CORTICOSTEROID TOXICITY IN CHILDREN.
Archives of disease in childhood 2016 Sep;101;e2 2016 Sep
Risk factors of severe infections in patients with rheumatoid arthritis treated with leflunomide.
Modern rheumatology 2013 Jul;23;709-15 2013 Jul
Clinical characteristics of Nocardia infection in patients with rheumatic diseases.
Clinical & developmental immunology 2013;2013;818654 2013
Invasive aspergillosis involving the lungs and brain after short period of steroid injection: a case report.
Tuberculosis and respiratory diseases 2012 May;72;448-51 2012 May
Pulmonary mucormycosis.
Seminars in respiratory and critical care medicine 2011 Dec;32;693-702 2011 Dec
Clinical picture of Pneumocystis jiroveci pneumonia in cancer patients.
Chest 2007 Oct;132;1305-10 2007 Oct
Anti-rheumatic drug use and risk of serious infections in rheumatoid arthritis.
Rheumatology (Oxford, England) 2007 Jul;46;1157-60 2007 Jul
Pneumocystis carinii pneumonia: the time course of clinical and radiographic improvement.
Chest 2003 Nov;124;1820-3 2003 Nov
Pulmonary infiltrates in patients receiving long-term glucocorticoid treatment: etiology, prognostic factors, and associated inflammatory response.
Chest 2003 Feb;123;488-98 2003 Feb
Low dose long-term corticosteroid therapy in rheumatoid arthritis: an analysis of serious adverse events.
The American journal of medicine 1994 Feb;96;115-23 1994 Feb
Serious infectious complications of corticosteroid therapy for COPD.
Chest 1989 Jun;95;1180-4 1989 Jun

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