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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Selective serotonin reuptake inhibitors (SSRI)- Serotonergic drugs

2

VI.y Pulmonary hypertension of the newborn (Persistent PHT)

2
Last update : 05/12/2013
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Antidepressants
3
Clomipramine
1
Duloxetine
1
Fluoxetine
2
Olanzapine
1
Paroxetine
1
Sertraline
3
Venlafaxine
2

Publications

Prenatal exposure to antidepressants and persistent pulmonary hypertension of the newborn: systematic review and meta-analysis.
BMJ (Clinical research ed.) 2014 Jan 14;348;f6932 2014 Jan 14
Pathophysiology, management, and outcome of persistent pulmonary hypertension of the newborn: a clinical review.
Frontiers in pediatrics 2013 Sep 02;1;23 2013 Sep 02
Safety of selective serotonin reuptake inhibitors in pregnancy.
CNS drugs 2009;23;493-509 2009

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