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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Selective serotonin reuptake inhibitors (SSRI)- Serotonergic drugs

2
Last update : 29/05/2023
I - Interstitial/parenchymal lung disease

I.c Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

1

I.e Acute eosinophilic pneumonia (AEP)

1
VI - Pulmonary vasculopathies

VI.b Pulmonary arterial hypertension

2

VI.w Worsening of preexisting PHTn

1

VI.y Pulmonary hypertension of the newborn (Persistent PHT)

2
XII - Cardiovascular involvement / toxicity

XII.ai Cardiotoxicity

2
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Antidepressants
3
Clomipramine
1
Duloxetine
1
Fluoxetine
2
Olanzapine
1
Paroxetine
1
Sertraline
3
Venlafaxine
2

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