Silicone embolism (SE) - SE syndrome

A life-threatening syndrome that follows subcutaneous or i.v. injection of fluid silicone. The clinical presentation includes pulmonary infiltrates, ALI/ARDS, DAH, and CNS involvement when silicone accesses the brain (the 'silicone embolism syndrome or SES). See also under VIg, VIh and under 'Pathology' XVbn

Last update : 06/11/2015

Causative drugs


Silicone (fluid)

I.a I - Interstitial/parenchymal lung disease
I.a - Pneumonitis (ILD), acute, severe (see also under ARDS)
I.b I - Interstitial/parenchymal lung disease
I.b - Pneumonitis (ILD)
I.k I - Interstitial/parenchymal lung disease
I.k - Lung nodule or nodules
I.z I - Interstitial/parenchymal lung disease
I.z - Areas of consolidation I - Interstitial/parenchymal lung disease - Silicone pneumonitis - 'Silicone lung'
II.b II - Pulmonary edema - ARDS - Acute respiratory failure
III.a III - Pulmonary hemorrhage
III.a - Diffuse alveolar hemorrhage (DAH)
VI.m VI - Pulmonary vasculopathy
VI.m - Silicone embolism (SE) - SE syndrome
VII.k VII - Mediastinal involvement
VII.k - Mediastinal silicone infiltration
VIII.k VIII - Upper, central, large airway involvement
VIII.k - Submucosal airway petechiae/hemorrhage
X.u X - Systemic conditions, syndromes and reactions
X.u - Multiple organ dysfunction/failure (MODS/MOF)
XI.b XI - Miscellaneous
XI.b - Chest pain (acute - subacute)
XI.aa XI - Miscellaneous
XI.aa - CNS symptoms or involvement, stroke
XV.c XV - Pulmonary pathology
XV.c - Path: Organizing pneumonia (OP/BOOP) pattern (see also Id)
XV.g XV - Pulmonary pathology
XV.g - Path: Alveolar hemorrhage (see also IIIa) XV - Pulmonary pathology - Path: Silicone in lung tissue, pulmonary vasculature or pleura XV - Pulmonary pathology - Path: Siliconoma
XVI.b XVI - Imaging
XVI.b - Imaging: Ground-glass shadowing/opacities (GGO)
XVI.e XVI - Imaging
XVI.e - Imaging: Pulmonary opacities with a subpleural distribution XVI - Imaging - Imaging: Foreign body pulmonary embolism
XIX.d XIX - Cytology, biochemistry of BAL, pleural fluid or FNA
XIX.d - BAL: Gross or microscopic bleeding/hemorrhage
XIX.l XIX - Cytology, biochemistry of BAL, pleural fluid or FNA
XIX.l - BAL: Silicone globules in macrophages