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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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VIII.ao

Laryngeal injury

Last update : 01/01/1970
 

Causative drugs

2

Amikacin, inhaled

III.c III - Pulmonary/alveolar./airway hemorrhage/bleeding
III.c - Hemoptysis
IV.a IV - Airway involvement
IV.a - Bronchospasm - Wheezing - Asthma
IV.f IV - Airway involvement
IV.f - Severe or catastrophic bronchospasm or asthma attack (can be fatal)
VIII.h VIII - Central-large-upper airway (incl. pharyngeal-nasal) involvement
VIII.h - Vocal cord dysfunction, adduction, closure, injury
VIII.j VIII - Central-large-upper airway (incl. pharyngeal-nasal) involvement
VIII.j - Laryngeal disorder: dysphonia, hoarseness
VIII.ao VIII - Central-large-upper airway (incl. pharyngeal-nasal) involvement
VIII.ao - Laryngeal injury
1

Antibiotics, inhaled

IV.a IV - Airway involvement
IV.a - Bronchospasm - Wheezing - Asthma
VIII.h VIII - Central-large-upper airway (incl. pharyngeal-nasal) involvement
VIII.h - Vocal cord dysfunction, adduction, closure, injury
VIII.t VIII - Central-large-upper airway (incl. pharyngeal-nasal) involvement
VIII.t - Vocal cord paresis/paralysis
VIII.ao VIII - Central-large-upper airway (incl. pharyngeal-nasal) involvement
VIII.ao - Laryngeal injury
1
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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