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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Angiotensin converting enzyme inhibitors (ACEI)

5

VIII.q Tongue involvement (edema, glossitis, hematoma)

3

Can be unilateral (PMID 20529395)

Last update : 05/07/2014
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Alteplase (rTPA)
2
Angiotensin II receptor blockers (ARB) - Sartans
3
Benazepril
1
Captopril
4
Cilazapril
1
Enalapril
3
Fosinopril
1
Gliptins
2
Imidapril
1
Lisinopril
5
Perindopril
1
Ramipril
2
Sacubitril
1
Sitagliptin
1
Trandolapril
1

Publications

A Rare Case of Unilateral Tongue Edema with Angiotensin Converting Enzyme Inhibitors.
Acta medica portuguesa 2022 Jul 01;35;588-590 2022 Jul 01
Macroglossia secondary to lisinopril-induced acute angioedema.
Proceedings (Baylor University. Medical Center) 2019 Jan;32;70-72 2019 Jan
Potentially lethal ACE-inhibitor-induced angioedema in a child.
Clinical case reports 2015 Jun;3;427-30 2015 Jun
Angiotensin-converting enzyme inhibitor-induced unilateral tongue angioedema.
The American journal of the medical sciences 2012 Nov;344;416-7 2012 Nov
Episodic macroglossia as the sole manifestation of angiotensin-converting enzyme inhibitor-induced angioedema.
The Annals of otology, rhinology, and laryngology 2004 Mar;113;223-4 2004 Mar
[Angioneurotic edema of the tongue, induced by administration of ACE inhibitors].
HNO 1990 Apr;38;143-4 1990 Apr

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