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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Angiotensin converting enzyme inhibitors (ACEI)

5

IV.a Bronchospasm - Wheezing - Asthma

1
Last update : 28/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Alteplase (rTPA)
2
Angiotensin II receptor blockers (ARB) - Sartans
3
Benazepril
1
Captopril
4
Cilazapril
1
Enalapril
3
Fosinopril
1
Gliptins
2
Imidapril
1
Lisinopril
5
Perindopril
1
Ramipril
2
Sacubitril
1
Sitagliptin
1
Trandolapril
1

Publications

Life-threatening bronchospasm induced by an angiotensin-converting enzyme inhibitor in a chronically ventilated patient: Diagnostic pitfalls and literature review.
Respirology case reports 2023 Oct;11;e01224 2023 Oct
The presence of underlying asthma should be investigated in patients diagnosed with ACE inhibitor induced cough.
The clinical respiratory journal 2020 Apr;14;382-388 2020 Apr
ACE inhibitor-induced cough and bronchospasm. Incidence, mechanisms and management.
Drug safety 1996 Jul;15;72-8 1996 Jul
Angiotensin converting enzyme inhibitors and asthma.
BMJ (Clinical research ed.) 1994 Feb 26;308;593-4 1994 Feb 26
Captopril-related (and -induced?) asthma.
The American review of respiratory disease 1987 Oct;136;999-1000 1987 Oct

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