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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Angiotensin converting enzyme inhibitors (ACEI)

5

IV.d Cough (lone)

5
Last update : 28/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Alteplase (rTPA)
2
Angiotensin II receptor blockers (ARB) - Sartans
3
Benazepril
1
Captopril
4
Cilazapril
1
Enalapril
3
Fosinopril
1
Gliptins
2
Imidapril
1
Lisinopril
5
Perindopril
1
Ramipril
2
Sacubitril
1
Sitagliptin
1
Trandolapril
1

Publications

Falsely Accused? Insufficient Evidence to Conclude that Sitagliptin is a Cause of Chronic Cough.
Lung 2020 Apr;198;271-273 2020 Apr
Chronic Cough.
The New England journal of medicine 2016 Oct 20;375;1544-1551 2016 Oct 20
The incidence and clinical predictors of ACE-inhibitor induced dry cough by perindopril in 27,492 patients with vascular disease.
International journal of cardiology 2014 Oct 20;176;718-23 2014 Oct 20
Thoughts on one thousand chronic cough patients.
Lung 2012 Dec;190;593-6 2012 Dec
Angiotensin-converting enzyme (ACE) gene insertion/deletion polymorphism and ACE inhibitor-related cough: a meta-analysis.
PloS one 2012;7;e37396 2012
Angiotensin-converting enzyme inhibitor-induced cough: ACCP evidence-based clinical practice guidelines.
Chest 2006 Jan;129;169S-173S 2006 Jan
ACE inhibitor-induced cough and bronchospasm. Incidence, mechanisms and management.
Drug safety 1996 Jul;15;72-8 1996 Jul
[Intractable cough from enalapril].
Anales de medicina interna (Madrid, Spain : 1984) 1991 Dec;8;628 1991 Dec
The positive association of cough with angiotensin-converting enzyme inhibitors.
Pharmacotherapy 1989;9;82-7 1989
Safety profiles of the angiotensin-converting enzyme inhibitors.
Drugs 1988;35 Suppl 5;89-97 1988
Post-marketing surveillance of enalapril: experience in 11,710 hypertensive patients in general practice.
The Journal of the Royal College of General Practitioners 1987 Aug;37;346-9 1987 Aug

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