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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Opiates - Opioids - Opium

5

IX.p Disordered breathing during sleep - Sleep apnea

1
Last update : 26/11/2014
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Antidotes
1
Body packing
4
Cannabinoids - Cannabinoid receptor agonists (synthetic) (K2, Spice)
5
Cannabis oil, paste, resin-H oil-Cannabidiol (inhaled)
1
Diacetylmorphine
1
Ethanol (ethyl alcohol, 'alcohol')
5
Fentanyl
5
Heroin (inhaled, insufflated, snorted)
4
Heroin (intravenous)
5
MT-45
1
Morphine
5
Naloxone
2
Opioids (synthetic)
5
Opium
1
Sufentanil
2
U-47700
1

Publications

Prolonged Sleep Apnea in Two Patients with a History of Opium Abuse -A Case Report.
Iranian journal of otorhinolaryngology 2020 Mar;32;127-131 2020 Mar
Effects of Chronic Opioid Use on Sleep and Wake.
Sleep medicine clinics 2018 Jun;13;271-281 2018 Jun
Effects of Opioids Given to Facilitate Mechanical Ventilation on Sleep Apnea After Extubation in the Intensive Care Unit.
Sleep 2018 Jan 01;41; 2018 Jan 01
Opioids, respiratory depression, and sleep-disordered breathing.
Best practice & research. Clinical anaesthesiology 2017 Dec;31;469-485 2017 Dec
Opioids and Sleep-Disordered Breathing.
Chest 2016 Oct;150;934-944 2016 Oct
Chronic opioid use and central sleep apnea: a review of the prevalence, mechanisms, and perioperative considerations.
Anesthesia and analgesia 2015 Jun;120;1273-85 2015 Jun
Sleep-disordered breathing and chronic opioid therapy.
Pain medicine (Malden, Mass.) 2008;9;425-32 2008
Sleep-disordered breathing associated with long-term opioid therapy.
Chest 2003 Feb;123;632-9 2003 Feb

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