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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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VIII.z

An increased bite force

Last update : 02/12/2014
 

Causative drugs

1

Midazolam

IV.a IV - Airway involvement
IV.a - Bronchospasm - Asthma
VIII.z VIII - Upper, central, large airway involvement
VIII.z - An increased bite force
IX.f IX - Neuromuscular / CNS involvement - Disordered breathing during sleep
IX.f - Hiccup
IX.g IX - Neuromuscular / CNS involvement - Disordered breathing during sleep
IX.g - Hyperventilation, hypocapnia and alcalosis
X.f X - Systemic reactions, syndromes and conditions
X.f - Anaphylaxis
1
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Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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