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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Chemotherapy, antineoplastic

5

I.a Pneumonitis (ILD), acute and/or severe (may cause ARDS)

3
Last update : 11/04/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Amrubicin
1
Anthracyclines
5
Azacitidine
3
Bendamustine
1
Bleomycin
5
Bortezomib
2
Busulfan
5
Capecitabine
2
Carboplatin
3
Carmustine (BCNU)
3
Cetuximab
4
Chlorozotocin (DCNU)
1
Cisplatin
3
Crizotinib
4
Cyclophosphamide
4
Cytosine arabinoside - Aracytine - Cytarabine - Ara-C
3
Decitabine
1
Docetaxel
3
Doxorubicin - Adriamycin
3
Erlotinib
3
Etoposide
2
FOLFIRI chemotherapy regimen
1
FOLFOX chemotherapy regimen
3
Famotidine
1
Floxuridine
1
Fludarabine
3
Fluorouracil (5-FU)
3
Fotemustine
1
Gefitinib
5
Gemcitabine
5
Gemtuzumab
1
Hydroxyurea (hydroxycarbamide)
2
Ifosfamide
2
Immune checkpoint inhibitors (ICI) - ICI combinatorial Rx
5
Irinotecan
2
Lomustine (CCNU)
3
Melphalan
3
Methotrexate
5
Mitomycin C
3
Mitoxantrone
1
Nitrogen mustard
1
Nitrosoureas (suffixes '-NU', '-mustine')
4
Oxaliplatin-based regimens
4
Paclitaxel
5
Pemetrexed
3
Platinum salts
3
Procarbazine
2
Raltitrexed
1
Taxanes
4
Temozolomide
2
Teniposide
1
Topotecan
1
Trofosfamide
1
Tyrosine kinase inhibitors (EGFR) TKI
5
Vinblastine
2
Vindesine
2
Vinorelbine
1
Zinostatin
1

Publications

Pneumonitis and pulmonary fibrosis in a patient receiving adjuvant docetaxel and cyclophosphamide for stage 3 breast cancer: a case report and literature review.
Journal of medical case reports 2012 Nov 30;6;413 2012 Nov 30
Interstitial pneumonia arising in a patient treated with oxaliplatin, 5-fluorouracil, and, leucovorin (FOLFOX).
International journal of clinical oncology 2009 Oct;14;457-9 2009 Oct
Pulmonary toxicity following carmustine-based preparative regimens and autologous peripheral blood progenitor cell transplantation in hematological malignancies.
Bone marrow transplantation 2000 Feb;25;309-13 2000 Feb
Effective treatment of advanced breast cancer with vinorelbine, mitomycin C plus human granulocyte colony-stimulating factor.
British journal of cancer 1996 Nov;74;1668-73 1996 Nov

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