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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Chemotherapy, antineoplastic

5

II.b ARDS - Acute lung injury

4
Last update : 14/07/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Amrubicin
1
Anthracyclines
5
Azacitidine
3
Bendamustine
1
Bleomycin
5
Bortezomib
2
Busulfan
5
Capecitabine
2
Carboplatin
3
Carmustine (BCNU)
3
Cetuximab
4
Chlorozotocin (DCNU)
1
Cisplatin
3
Crizotinib
4
Cyclophosphamide
4
Cytosine arabinoside - Aracytine - Cytarabine - Ara-C
3
Decitabine
1
Docetaxel
3
Doxorubicin - Adriamycin
3
Erlotinib
3
Etoposide
2
FOLFIRI chemotherapy regimen
1
FOLFOX chemotherapy regimen
3
Famotidine
1
Floxuridine
1
Fludarabine
3
Fluorouracil (5-FU)
3
Fotemustine
1
Gefitinib
5
Gemcitabine
5
Gemtuzumab
1
Hydroxyurea (hydroxycarbamide)
2
Ifosfamide
2
Immune checkpoint inhibitors (ICI) - ICI combinatorial Rx
5
Irinotecan
2
Lomustine (CCNU)
3
Melphalan
3
Methotrexate
5
Mitomycin C
3
Mitoxantrone
1
Nitrogen mustard
1
Nitrosoureas (suffixes '-NU', '-mustine')
4
Oxaliplatin-based regimens
4
Paclitaxel
5
Pemetrexed
3
Platinum salts
3
Procarbazine
2
Raltitrexed
1
Taxanes
4
Temozolomide
2
Teniposide
1
Topotecan
1
Trofosfamide
1
Tyrosine kinase inhibitors (EGFR) TKI
5
Vinblastine
2
Vindesine
2
Vinorelbine
1
Zinostatin
1

Publications

Severe Complications in Testicular Germ Cell Tumors: The Choriocarcinoma Syndrome.
Frontiers in endocrinology 2019;10;218 2019
Fatal Interstitial Pneumonitis Rapidly Developed after the First Cycle of CHOP with Etoposide Combination Chemotherapy in a Patient with Lymphoma.
Tuberculosis and respiratory diseases 2013 May;74;235-9 2013 May
Drug-associated acute lung injury: a population-based cohort study.
Chest 2012 Oct;142;845-850 2012 Oct
Severe pulmonary toxicity after myeloablative conditioning using total body irradiation: an assessment of risk factors.
International journal of radiation oncology, biology, physics 2011 Nov 01;81;812-8 2011 Nov 01
The pathologist's approach to acute lung injury.
Archives of pathology & laboratory medicine 2010 May;134;719-27 2010 May
Pulmonary toxicity after a quick course of combinatorial vincristine, bleomycin, and cisplatin neoadjuvant chemotherapy in cervical cancer.
Journal of Korean medical science 2010 Feb;25;240-4 2010 Feb
My approach to interstitial lung disease using clinical, radiological and histopathological patterns.
Journal of clinical pathology 2009 May;62;387-401 2009 May
Severe pulmonary toxicity in patients with advanced-stage Hodgkin's disease treated with a modified bleomycin, doxorubicin, cyclophosphamide, vincristine, procarbazine, prednisone, and gemcitabine (BEACOPP) regimen is probably related to the combination of gemcitabine and bleomycin: a report of the German Hodgkin's Lymphoma Study Group.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2004 Jun 15;22;2424-9 2004 Jun 15
Pulmonary toxicity syndrome following CDEP (cyclophosphamide, dexamethasone, etoposide, cisplatin) chemotherapy.
Bone marrow transplantation 2001 Aug;28;399-403 2001 Aug
Effective treatment of advanced breast cancer with vinorelbine, mitomycin C plus human granulocyte colony-stimulating factor.
British journal of cancer 1996 Nov;74;1668-73 1996 Nov
Chemotherapy-associated pulmonary toxic reactions during treatment for breast cancer.
Archives of internal medicine 1984 May;144;953-6 1984 May
Review: diagnosis of chemotherapy lung.
AJR. American journal of roentgenology 1981 Jan;136;33-40 1981 Jan

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