III.a

Alveolar hemorrhage (AH), diffuse AH (DAH)

(Fr: hémorragie alvéolaire pure, isolée, sans auto-Ac). Diffuse bland alveolar hemorrhage (DAH). Can be severe or fatal (PMID 26236607). When unassociated with pulmonary vasculitis or capillaritis, the condition is named bland diffuse alveolar hemorrhage (DAH). Caution: hemosiderin-laden BAL macrophages can be found in DAD (PMID 19129275). Laboratory clues to this condition include ANA, ANCA, platelets and coagulation studies (INR, and full blood count). DAH may unravel thrombocytopenia, coaculopathy, ANA- or ANCA- and, less often, anti-GBM-related disease. Pulmonary capillaritis is more often suspected than proved, as the lung biopsy is generally avoided if typical BAL features are present. ANCA of MPO-, HNE- or, less often, -PR3 with multispecificity and high titers suggest the drug etiology. Drug-induced DAH can mimic primary ANCA-related micropolyangiitis or 'Wegener's'. See PMID 19592204, 20442117, 21606695, 21674416. A search for underlying pulmonary condition at the origin of hemorrhage (e.g. lung cancer, bronchiectasis) is indicated. See also under IIIb, VId, Xs, Xz, XVIIv. 2018 review @PMID 30404115

Last update : 01/01/1970
 

Causative drugs

155

Warfarin

I.i I - Interstitial/parenchymal lung disease
I.i - Diffuse pulmonary calcification (calciphylaxis)
I.y I - Interstitial/parenchymal lung disease
I.y - Progression, acceleration or exacerbation of preexisting ILD/fibrosis
III.a III - Pulmonary/alveolar./airway hemorrhage/bleeding
III.a - Alveolar hemorrhage (AH), diffuse AH (DAH)
III.c III - Pulmonary/alveolar./airway hemorrhage/bleeding
III.c - Hemoptysis
III.e III - Pulmonary/alveolar./airway hemorrhage/bleeding
III.e - Pulmonary hematoma
III.l III - Pulmonary/alveolar./airway hemorrhage/bleeding
III.l - Alveolar hemorrhage, localized (e.g. lobar)
IV.af IV - Airway involvement
IV.af - Calcification of tracheobronchial cartilaginous rings
V.b V - Pleural and/or pericardial involvement
V.b - Eosinophilic pleural effusion
V.n V - Pleural and/or pericardial involvement
V.n - Hemopericardium - Bloody pericardial effusion
VII.g VII - Mediastinal involvement
VII.g - Hemomediastinum - Mediastinal hematoma
VIII.b VIII - Central-large-upper airway (incl. pharyngeal-nasal) involvement
VIII.b - Hematoma of/around central airway wall potentially causing UAO
VIII.q VIII - Central-large-upper airway (incl. pharyngeal-nasal) involvement
VIII.q - Tongue involvement (edema, glossitis, hematoma)
IX.x IX - Neuromuscular / CNS involvement - Disordered breathing during sleep
IX.x - Thoracic epidural or spinal hematoma
XI.k XI - Miscellaneous
XI.k - Esophageal hematoma (may cause chest pain and/or tracheal compression)
XI.aj XI - Miscellaneous
XI.aj - Congenital respiratory malformations in the fetus
XI.ar XI - Miscellaneous
XI.ar - Calciphylaxis
XII.ar XII - Cardiovascular involvement / toxicity
XII.ar - Calcification of the coronary artery walls or atheroma
2