Negative pressure pulmonary edema (NPPE)

See also under negative pressure pulmonary hemorrhage IIIf. (Fr: OAP par obstruction des VAS et pression négative inspiratoire). NPPE develops as an rapid-onset consequence of large negative intrathoracic pressure swings against a closed airway. Tracheal petechiae have been noted in some cases: PMID 21362660. Common causes include tonsillar enlargement/surgery, obstruction of the upper/large airway, angioedema, recent extubation, thyroid conditions, vocal cord surgery. Pathophysiology at PMID 23640584. Review at PMID 25445940

Last update : 01/01/1970

Causative drugs


Ethanol (ethyl alcohol, 'alcohol')

II.b II - Pulmonary edema - Acute lung injury - ARDS
II.b - ARDS - Acute lung injury
II.g II - Pulmonary edema - Acute lung injury - ARDS
II.g - Negative pressure pulmonary edema (NPPE)
IV.a IV - Airway involvement
IV.a - Bronchospasm - Wheezing - Asthma
VI.a VI - Pulmonary vasculopathies
VI.a - Pulmonary embolism - Venous thrombosis/thromboembolism
VI.l VI - Pulmonary vasculopathies
VI.l - Acute pulmonary vasoconstriction and PHT
VIII.y VIII - Central-large-upper airway (incl. pharyngeal-nasal) involvement
VIII.y - Sinonasal discharge, -blockage, -obstruction
IX.d IX - Neuromuscular / CNS involvement - Disordered breathing during sleep
IX.d - Respiratory failure from ventilatory depression (due to neuromuscular blockade/paralysis)
X.f X - Systemic/Distant conditions, syndromes and reactions
X.f - Anaphylaxis-Anaphylactoid reaction (can be fatal)
XI.b XI - Miscellaneous
XI.b - Chest pain (acute or subacute), lone or prominent
XI.g XI - Miscellaneous
XI.g - Aspiration, aspiration pneumonia (w/wo demonstrable pharyngeal dysmotility)
XI.h XI - Miscellaneous
XI.h - Esophageal pathology (erosion, ulcer, tear, rupture, fistula)
XI.r XI - Miscellaneous
XI.r - Death following exposure or poisoning
XII.af XII - Cardiovascular involvement / toxicity
XII.af - Coronary vasospasm - Vasospastic angina
XVII.a XVII - Infections & related conditions
XVII.a - Respiratory tract infection incl. pneumonia
XVII.b XVII - Infections & related conditions
XVII.b - Opportunistic pulmonary/systemic infections